Biology

Allometric Scaling

This is topic is a by-product of the General growth law. At some point, I found the allometric scaling relationships between the shape of organisms and the amount of consumed nutrients (more on that in the book "Growth as a union of form and biochemistry. How the unity of geometry and chemistry creates living worlds through fundamental law of nature - the General growth law ". 2014. AKVY Press, 456 p"). Then, several articles were written, of which only one was published (the list of articles and preprints is below). The rest is in a tedious process of publishing. 

1. Shestopaloff Yu. K. (2016). Metabolic allometric scaling model. Combining cellular transportation  and heat dissipation constraints. Journal of Experimental Biology, 219, 2481-2489.

2. Shestopaloff Yu. K. (2016). Biophysical growth and reproduction mechanisms of cells and first principles of life origin and development. Preprint. arXiv:1609.09421 [q-bio.OT], https://arxiv.org/abs/1609.09421 (presently under review in Acta Biotheoretica)

 3. Shestopaloff Yu. K. (2016). Interspecific allometric scaling of unicellular organisms as an
evolutionary process of food chain creation. Preprint. arXiv:1611.09824 [q-bio.OT], http://arxiv.org/abs/1611.09824

4. Shestopaloff Yu. K. (2016). Interspecific allometric scaling of multicellular organisms as an evolutionary process of food chain creation, influenced by mechanical constraints. Preprint. arXiv: 1612.00098 [q-bio.OT], http://arxiv.org/abs/1612.00098

5. Shestopaloff Yu. K. (2016). The role of food chain balance and common nutritional environment in interspecific allometric scaling of unicellular organisms. Preprint. arXiv:1612.04695 [q-bio.OT], http://arxiv.org/abs/1612.04695

6.  Shestopaloff Yu. K. (2017). The role of ecological and phylogenetic factors in the problem of interspecific metabolic allometric scaling. Preprint.

 

General Growth Mechanism.

Modeling Growth of Cells and other Living Organisms

    At this point, the author has published four books about the growth of living organisms, and 8 articles. The material presents the general growth mechanism. It is difficult to comprehend this kind of discoveries, because of the fundamental nature of this mechanism. Essentially, this growth mechanism presents one of the fundamental laws of Nature that universally governs development of all living organisms and their constituents. The results of research confirmed the validity of this hypothesis with regard to growth of cells and organs. The author also collected numerous facts and observations of his own and in the literature, which indicate that this mechanism also governs the evolvement of multicellular organisms and, in fact, all living species. Many facts and observations prove the hypothesis indirectly, but the abundance of such material and the perfect fit of observations into the framework of the discovered general growth mechanism make the hypothesis very credible.

 

            The reader can refer to the following books.

       

1.      Yuri K. Shestopaloff, "Growth and replication of living organisms. General law of growth and replication and the unity of biochemical and physical mechanisms", 2012, Second Edition, 246 p.

2. Yuri K. Shestopaloff, "Growth and replication of living organisms. General law of growth and replication and the unity of biochemical and physical mechanisms", 2011, 215 p.

3. "Bioinformatics". Collective monograph. Chapter on growth of living organisms. Editor in Chief P. H. Pawlowski,  Vol. 10, Polish Academy of Science, Exit-C, p. 361-386.

4. Yuri K. Shestopaloff, "Physics of Growth and Replication. Physical and Geometrical Perspectives on Living Organisms' Development", AKVY Press, 2010, 174 p.

5. Yuri K. Shestopaloff, "Growth and Replication of Cells and Other Living Organisms. Physical Mechanisms that Govern Nature’s Evolvement", AKVY Press, 2009, 82 p.

6. Yu. K. Shestopaloff, "Growth and replication of living organisms. General law of growth and replication and the unity of biochemical and physical mechanisms", 2013, 3d revised edition, 257 p.

7. Yu. K. Shestopaloff, "Growth as a union of form and biochemistry. How the unity of geometry and chemistry creates living worlds through fundamental law of nature - the General growth law ". 2014. AKVY Press, 456 p.

 

Articles on different aspects of this subject have been published in the following journals.

 

1.         Shestopaloff Yu. K., "The Role of Physical and Geometrical Factors in the Growth of Living Organisms", Biophysical Reviews and Letters, Vol. 5, No. 1 (2010), p. 43-58. DOI No: 10.1142/S1793048010001111

2.         Shestopaloff Yu. K. "A mathematical model of the physical growth mechanism and geometrical characterization of growing forms", International Journal of Biomathematics, 2011, Vol. 4, No. 1, p. 35-53. DOI: 10.1142/S1793524511001180

3.         Shestopaloff Yu. K. "The law of growth and replication ", Almanac "Lebed", 2012, No. 665, http://www.lebed.com/2012/art6096.htm.

4.         Shestopaloff Yu. K. "General law of growth and replication, growth equation and its applications", Biophysical Reviews and Letters, 2012 Vol. 7, No. 1-2, p. 71-120. DOI: 10.1142/S1793048012500051 http://www.worldscientific.com/doi/abs/10.1142/S1793048012500051 Free download (Open access publication)

5.         Shestopaloff Yu. K. "Predicting growth and finding biomass production using the general growth mechanism", Biophysical Reviews and Letters, 2012 Vol. 7, No. 3-4, p. 177-195. DOI: 10.1142/S1793048012500075

6.         Shestopaloff Yu. K. A general method for modeling population dynamics and its applications. Acta Biotheoretica. 2013, Vol.61, Issue 4, 499-519. DOI 10.1007/s10441-013-9202-8, http://link.springer.com/article/10.1007%2Fs10441-013-9202-8

7.         Shestopaloff Yu. K., Sbalzarini I. F. (2014) A method for modeling growth of organs and transplants based on the general growth law: Application to the liver in dogs and humans. PLoS ONE 9(6): e99275. doi:10.1371/journal.pone.0099275

8.          Shestopaloff Yu. K. (2014) Method for finding metabolic properties based on the general growth law. Liver examples. A General framework for biological modeling. PLoS ONE 9(6): e99836. doi:10.1371/journal.pone.0099836

9.    Shestopaloff Yu. K. (2015) Why cells grow and divide? General growth mechanism and how it defines cells' growth, reproduction and metabolic properties. Biophysical Reviews and Letters.  10(4), 209-256. Supporting material is below.

Supporting material

Set of computed growth curves versus experimental data for 32oC

Set of computed growth curves versus experimental data for 25oC

 

Experimental data were obtained by Baumgartner, S., Tolic-Norrelykke, I. M., in the study done at Max

Planck Institute of Molecular Cell Biology and Genetics. Results were published in the article: "Baumgartner, S., Tolic-Norrelykke, I. M., 2009. Growth pattern of single fission yeast cells is bilinear and depends on temperature and DNA synthesis. Biophys. J. 96(10), 4336-4347."